Tablet treatments for psoriasis include both prescription medications and over-the-counter tablets available from pharmacies and health food shops.

When determining whether tablet treatments are right for you, our specialists will consider the severity of your psoriasis and its impact on your life and weigh this against the risk of treatment.

  • Most effective tablet treatments for psoriasis require a prescription from a doctor
  • Tablets are usually most effective in managing severe or more widespread psoriasis
  • The choice of tablet must be determined by the doctor depending on factors such as lifestyle, other medical problems and plans for pregnancy
  • When supervised by our specialists, tablet treatments can be both safe and effective

For more severe psoriasis (covering more than 10-20% of the skin surface) or for psoriasis that has not been helped by topical or ultraviolet light treatments, tablets may be required.

Tablet treatments are usually necessary for psoriasis that interferes with daily activities such as hand psoriasis or foot psoriasis. Psoriasis affecting the nails and unstable psoriasis may also require tablet treatment. Some patients with arthritis of the joints related to their psoriasis can benefit from tablets.

Many vitamin and nutrient based supplements have been used throughout history for treating psoriasis. These have included zinc, selenium, vitamins such as A, B, C, D and E, fish oil, herbal products and even homeopathic formulations. Whilst a normal, healthy diet often provides adequate vitamins and minerals, where deficiencies in these vitamins and nutrients exist, supplements may be of benefit.

While tablet treatments can help reduce or clear more severe psoriasis, these medications can sometimes cause serious side effects and must be carefully monitored by your dermatologist.

The most common tablets used in the systemic treatment for psoriasis include methotrexate, cyclosporine and acitretin.

Certain tablets are compatible with narrowband phototherapy. Vitamin A tablets such as acitretin can be used with UV therapy, and in many cases clear psoriasis at a much quicker rate than taking tablets only. Your specialist will discuss if this treatment is for you.

Not all people with psoriasis will need tablets. Prescription medication is limited to the patients who fail to respond to creams, phototherapy, and diet. Your specialist practitioner will inform you if you are suitable for tablets and will take the necessary time to discuss treatment options with you.

The Institute practices a holistic approach to the treatment of psoriasis, including diets. Some, but not all cases of psoriasis will respond to diet. Discuss with your psoriasis practitioner if you would like to be referred to our psoriasis specialist dietitian.

Other natural treatments include:

Natural sunlight and Phototherapy

Vitamins and supplements



  • I had been told so many things about psoriasis. I was so confused. After seeing the Institute team I now have a plan in place that I understand and managing my psoriasis is much simpler.
    - Kathryn G, St Lucia

Tablets are usually most effective in managing severe or more widespread psoriasis